BDBM717666 US20250034173, Example 54

SMILES C[C@@H]9CCCc8cc1[nH]ncc1c(c5nc6OC[C@@H]2COCCCN2c7nc(OC[C@@]34CCCN3C/C(=C/F)C4)nc(c5F)c67)c89

InChI Key InChIKey=JWIOJKMNLARBIL-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 717666   

TargetGTPase KRas(Human)
Pfizer

US Patent
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd:  1nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Pfizer

US Patent
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd:  1nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Pfizer

US Patent
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd: <1nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
Pfizer

US Patent
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd:  1nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase HRas(Human)
Pfizer

US Patent
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase NRas(Human)
Pfizer

US Patent
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent