BDBM717656 US20250034173, Example 44

SMILES OC/C=C\9CN1CCC[C@@]1(COc6nc7c5c(nc(c3c(C2CC2)c(Cl)cc4[nH]ncc34)c(F)c5n6)OC[C@@H]8COCCCN78)C9

InChI Key InChIKey=AEJWFGGXRVSTBD-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 717656   

TargetGTPase KRas [G12D](Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 717656BDBM717656(US20250034173, Example 44)
Affinity DataKd:  2nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 717656BDBM717656(US20250034173, Example 44)
Affinity DataKd:  3nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 717656BDBM717656(US20250034173, Example 44)
Affinity DataKd:  3nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 717656BDBM717656(US20250034173, Example 44)
Affinity DataKd:  3nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent