BDBM717652 (General method C): (8aS)-5-(6-chloro-5-cyclopropyl-1H-indazol-4-yl)-2-{[(7aS)-2-cyclopropylidenetetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}-4-fluoro-8a,9,12,13-tetrahydro-8H,11H-7,10-dioxa-1,3,6,13a-tetraazanaphtho[1,8-ab]heptalene::US20250034173, Example 40

SMILES Fc1c(-c2c(C3CC3)c(Cl)cc3[nH]ncc23)nc2c3c(nc(OC[C@@]45CCCN4CC(=C4CC4)C5)nc13)N1CCCOC[C@H]1CO2

InChI Key InChIKey=VSWXQUHTBRKEJD-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 717652   

TargetGTPase KRas(Human)
Pfizer

US Patent
LigandPNGBDBM717652((General method C): (8aS)-5-(6-chloro-5-cyclopropy...)
Affinity DataKd:  6nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Pfizer

US Patent
LigandPNGBDBM717652((General method C): (8aS)-5-(6-chloro-5-cyclopropy...)
Affinity DataKd:  4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Pfizer

US Patent
LigandPNGBDBM717652((General method C): (8aS)-5-(6-chloro-5-cyclopropy...)
Affinity DataKd:  7nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
Pfizer

US Patent
LigandPNGBDBM717652((General method C): (8aS)-5-(6-chloro-5-cyclopropy...)
Affinity DataKd:  6nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent