BDBM717636 (General method B): (8aS)-5-[6-chloro-5-(propan-2-yl)-1H-indazol-4-yl]-4-fluoro-2-{[(7aS)-2-methylidenetetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}-8a,9,12,13-tetrahydro-8H,11H-7,10-dioxa-1,3,6,13a-tetraazanaphtho[1,8-ab]heptalene::US20250034173, Example 24

SMILES C=C1CN2CCC[C@@]2(COc2nc3c4c(nc(-c5c(C(C)C)c(Cl)cc6[nH]ncc56)c(F)c4n2)OC[C@@H]2COCCCN32)C1

InChI Key InChIKey=NBTZLRCXXQXMFO-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 717636   

TargetGTPase KRas(Human)
Pfizer

US Patent
LigandPNGBDBM717636((General method B): (8aS)-5-[6-chloro-5-(propan-2-...)
Affinity DataKd:  7nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Pfizer

US Patent
LigandPNGBDBM717636((General method B): (8aS)-5-[6-chloro-5-(propan-2-...)
Affinity DataKd:  5nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Pfizer

US Patent
LigandPNGBDBM717636((General method B): (8aS)-5-[6-chloro-5-(propan-2-...)
Affinity DataKd:  4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
Pfizer

US Patent
LigandPNGBDBM717636((General method B): (8aS)-5-[6-chloro-5-(propan-2-...)
Affinity DataKd:  5nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase HRas(Human)
Pfizer

US Patent
LigandPNGBDBM717636((General method B): (8aS)-5-[6-chloro-5-(propan-2-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase NRas(Human)
Pfizer

US Patent
LigandPNGBDBM717636((General method B): (8aS)-5-[6-chloro-5-(propan-2-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent