BDBM717528 US20250034165, Example 70

SMILES Cc1cc2cc(n1)-c1cnn(C)c1OCCC[C@@H](C1CC1)CN1/C(=N/C2=O)Nc2cc(NCCCN3CCCC3)ccc21

InChI Key InChIKey=BTLPUHUJPPTSEE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 717528   

TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717528(US20250034165, Example 70)
Affinity DataIC50: 0.990nMAssay Description:A 50 ng/μL EGFR (WT, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 20), and 6 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor (EGFR)(L858R)(T790M)(Human)
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717528(US20250034165, Example 70)
Affinity DataIC50: 0.0150nMAssay Description:A 50 ng/μL EGFR (L858R/T790M, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 20),...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-745,751-1210,T790M](Human)
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717528(US20250034165, Example 70)
Affinity DataIC50: 0.0130nMAssay Description:A 50 ng/μL EGFR (d746-750/T790M, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717528(US20250034165, Example 70)
Affinity DataIC50: 0.0290nMAssay Description:A 50 ng/μL EGFR (L858R/T790M/C797S, BPS) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-745,751-1210,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717528(US20250034165, Example 70)
Affinity DataIC50: 0.0400nMAssay Description:A 50 ng/μL EGFR (d746-750/T790M/C797S, BPS) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Twe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent