BDBM717458 (1r,3r)-3-{4-[6-(1,3-dimethyl- 1H-pyrazol-4-yl)furo[2,3- d]pyrimidin-4-yl]-3-(4- fluorophenyl)-1H-pyrazol-1- yl}cyclobutane-1-carbonitrile::US20250034159, Example 279

SMILES Cc1nn(C)cc1-c1cc2c(-c3cn([C@H]4C[C@H](C#N)C4)nc3-c3ccc(F)cc3)ncnc2o1

InChI Key InChIKey=WQYORPRYQGLUSL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717458   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717458((1r,3r)-3-{4-[6-(1,3-dimethyl- 1H-pyrazol-4-yl)fur...)
Affinity DataIC50: 0.106nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent