BDBM717446 1-[4-{6-[5-(difluoromethyl)-1- methyl-1H-pyrazol-4- yl]furo[2,3-d]pyrimidin-4-yl}-3- (4-fluorophenyl)-1H-pyrazol-1- yl]-2-methylpropan-2-ol::US20250034159, Example 267

SMILES Cn1ncc(-c2cc3c(-c4cn(CC(C)(C)O)nc4-c4ccc(F)cc4)ncnc3o2)c1C(F)F

InChI Key InChIKey=FNONVWMHXJJGDH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717446   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717446(1-[4-{6-[5-(difluoromethyl)-1- methyl-1H-pyrazol-4...)
Affinity DataIC50: 0.185nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent