BDBM717443 4-{1-[(1s,3s)-3- fluorocyclobutyl]-3-(4- fluorophenyl)-1H-pyrazol-4-yl}- 6-(1-methyl-1H-imidazol-4- yl)furo[2,3-d]pyrimidine::US20250034159, Example 264

SMILES Cn1cnc(-c2cc3c(-c4cn([C@H]5C[C@@H](F)C5)nc4-c4ccc(F)cc4)ncnc3o2)c1

InChI Key InChIKey=MJYCNGIYVFQOCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717443   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717443(4-{1-[(1s,3s)-3- fluorocyclobutyl]-3-(4- fluorophe...)
Affinity DataIC50: 0.135nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent