BDBM717442 4-[1-(3,3-difluoropropyl)-3-(4- fluorophenyl)-1H-pyrazol-4-yl]- 6-(1-methyl-1H-imidazol-4- yl)furo[2,3-d]pyrimidine::US20250034159, Example 263

SMILES Cn1cnc(-c2cc3c(-c4cn(CCC(F)F)nc4-c4ccc(F)cc4)ncnc3o2)c1

InChI Key InChIKey=MKXLFICICLQGFG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717442   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717442(4-[1-(3,3-difluoropropyl)-3-(4- fluorophenyl)-1H-p...)
Affinity DataIC50: 0.153nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent