BDBM717438 4-{3-(4-fluorophenyl)-1-[(1s,3s)- 3-(methanesulfonyl)cyclobutyl]- 1H-pyrazol-4-yl}-6-(1-methyl- 1H-imidazol-4-yl)furo[2,3- d]pyrimidine::US20250034159, Example 259

SMILES Cn1cnc(-c2cc3c(-c4cn([C@H]5C[C@@H](S(C)(=O)=O)C5)nc4-c4ccc(F)cc4)ncnc3o2)c1

InChI Key InChIKey=AQTSLMNGEWIRAV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717438   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717438(4-{3-(4-fluorophenyl)-1-[(1s,3s)- 3-(methanesulfon...)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent