BDBM717431 1-{3-(4-fluorophenyl)-4-[6- (1,3,5-trimethyl-1H-pyrazol-4- yl)furo[2,3-d]pyrimidin-4-yl]- 1H-pyrazol-1-yl}-2- methylpropan-2-ol::US20250034159, Example 252

SMILES Cc1nn(C)c(C)c1-c1cc2c(-c3cn(CC(C)(C)O)nc3-c3ccc(F)cc3)ncnc2o1

InChI Key InChIKey=CEWQZSNQABQEPG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717431   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717431(1-{3-(4-fluorophenyl)-4-[6- (1,3,5-trimethyl-1H-py...)
Affinity DataIC50: 0.0900nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent