BDBM717426 (1R,3R)-3-[3-(4-fluorophenyl)-4- (6-phenylfuro[2,3-d]pyrimidin-4- yl)-1H-pyrazol-1-yl]-1-imino- 1lambda6-thiolan-1-one (absolute stereochemistry arbitrarily assigned)::US20250034159, Example 247

SMILES N=[S@@]1(=O)CC[C@@H](n2cc(-c3ncnc4oc(-c5ccccc5)cc34)c(-c3ccc(F)cc3)n2)C1

InChI Key InChIKey=CTNYLVUFOBCCBS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717426   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717426((1R,3R)-3-[3-(4-fluorophenyl)-4- (6-phenylfuro[2,3...)
Affinity DataIC50: 0.0900nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent