BDBM717362 2-{4-[1-(1,1-dioxo-1lambda6-thietan- 3-yl)-3-(4-fluorophenyl)-1H- pyrazol-4-yl]furo[2,3- d]pyrimidin-6-yl}benzamide::US20250034159, Example 183

SMILES NC(=O)c1ccccc1-c1cc2c(-c3cn(C4CS(=O)(=O)C4)nc3-c3ccc(F)cc3)ncnc2o1

InChI Key InChIKey=FSJRDOFTUIOGTI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 717362   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717362(2-{4-[1-(1,1-dioxo-1lambda6-thietan- 3-yl)-3-(4-fl...)
Affinity DataIC50: 0.140nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent