BDBM717288 1-[3-(2-fluorophenyl)-4-(6- phenylfuro[2,3-d]pyrimidin-4- yl)-1H-pyrazol-1-yl]-2- methylpropan-2-ol::US20250034159, Example 109

SMILES CC(C)(O)Cn1cc(-c2ncnc3oc(-c4ccccc4)cc23)c(-c2ccccc2F)n1

InChI Key InChIKey=DAJJBMMMJRGTJO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717288   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717288(1-[3-(2-fluorophenyl)-4-(6- phenylfuro[2,3-d]pyrim...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717288(1-[3-(2-fluorophenyl)-4-(6- phenylfuro[2,3-d]pyrim...)
Affinity DataIC50: 0.180nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent