BDBM717270 4-{3-(4-fluorophenyl)-1-[(3S)- oxolan-3-yl]-1H-pyrazol-4-yl}- 6-phenylfuro[2,3-d]pyrimidine (absolute stereochemistry arbitrarily assigned)::US20250034159, Example 91

SMILES Fc1ccc(-c2nn([C@H]3CCOC3)cc2-c2ncnc3oc(-c4ccccc4)cc23)cc1

InChI Key InChIKey=RCYCIRACLRYGOQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717270   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717270(4-{3-(4-fluorophenyl)-1-[(3S)- oxolan-3-yl]-1H-pyr...)
Affinity DataIC50: 0.370nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
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TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717270(4-{3-(4-fluorophenyl)-1-[(3S)- oxolan-3-yl]-1H-pyr...)
Affinity DataIC50: 0.230nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent