BDBM717242 4-[3-(4-fluorophenyl)-1-methyl- 1H-pyrazol-4-yl]-6- phenylfuro[2,3-d]pyrimidine::US20250034159, Example 63

SMILES Cn1cc(-c2ncnc3oc(-c4ccccc4)cc23)c(-c2ccc(F)cc2)n1

InChI Key InChIKey=LMKJKVJZYQVCGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717242   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717242(4-[3-(4-fluorophenyl)-1-methyl- 1H-pyrazol-4-yl]-6...)
Affinity DataIC50: 0.474nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717242(4-[3-(4-fluorophenyl)-1-methyl- 1H-pyrazol-4-yl]-6...)
Affinity DataIC50: 0.459nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent