BDBM717239 4-[3-(4-fluorophenyl)-1H- pyrazol-4-yl]-6-phenylfuro[2,3- d]pyrimidine::US20250034159, Example 60

SMILES Fc1ccc(-c2n[nH]cc2-c2ncnc3oc(-c4ccccc4)cc23)cc1

InChI Key InChIKey=CTMMAXJIOIGRIE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717239   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717239(4-[3-(4-fluorophenyl)-1H- pyrazol-4-yl]-6-phenylfu...)
Affinity DataIC50: 0.526nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717239(4-[3-(4-fluorophenyl)-1H- pyrazol-4-yl]-6-phenylfu...)
Affinity DataIC50: 0.419nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent