BDBM717231 3-{2-[3-(4-fluorophenyl)-4-(6- phenylfuro[2,3-d]pyrimidin-4- yl)-1H-pyrazol-1-yl]ethyl}-126- thietane-1,1-dione::US20250034159, Example 52

SMILES O=S1(=O)CC(CCn2cc(-c3ncnc4oc(-c5ccccc5)cc34)c(-c3ccc(F)cc3)n2)C1

InChI Key InChIKey=AXCNMZXKKKOLKF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717231   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717231(3-{2-[3-(4-fluorophenyl)-4-(6- phenylfuro[2,3-d]py...)
Affinity DataIC50: 0.307nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717231(3-{2-[3-(4-fluorophenyl)-4-(6- phenylfuro[2,3-d]py...)
Affinity DataIC50: 0.368nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent