BDBM717227 4-[3-(4-fluorophenyl)-1- (2H3)methyl-1H-pyrazol-4-yl]-6- phenylfuro[2,3-d]pyrimidine::US20250034159, Example 48

SMILES [2H]C([2H])([2H])n1cc(-c2ncnc3oc(-c4ccccc4)cc23)c(-c2ccc(F)cc2)n1

InChI Key InChIKey=LMKJKVJZYQVCGH-FIBGUPNXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717227   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717227(4-[3-(4-fluorophenyl)-1- (2H3)methyl-1H-pyrazol-4-...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717227(4-[3-(4-fluorophenyl)-1- (2H3)methyl-1H-pyrazol-4-...)
Affinity DataIC50: 0.374nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent