BDBM717210 4-[3-(4-fluorophenyl)-1-(oxetan- 3-yl)-1H-pyrazol-4-yl]-6- phenylfuro[2,3-d]pyrimidine::US20250034159, Example 31

SMILES Fc1ccc(-c2nn(C3COC3)cc2-c2ncnc3oc(-c4ccccc4)cc23)cc1

InChI Key InChIKey=FIKZULRUIVQEFM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717210   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717210(4-[3-(4-fluorophenyl)-1-(oxetan- 3-yl)-1H-pyrazol-...)
Affinity DataIC50: 0.521nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717210(4-[3-(4-fluorophenyl)-1-(oxetan- 3-yl)-1H-pyrazol-...)
Affinity DataIC50: 0.446nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent