BDBM717208 3-[4-(4-fluorophenyl)-5-{2-[4- (4-methylpiperazin-1-yl)phenyl]- 1H-pyrrolo[2,3-b]pyridin-4-yl}- 1,3-oxazol-2-yl]propan-1-ol::US20250034159, Example 29

SMILES CN1CCN(c2ccc(-c3cc4c(-c5oc(CCCO)nc5-c5ccc(F)cc5)ccnc4[nH]3)cc2)CC1

InChI Key InChIKey=BKNGWTKOHKWRIM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717208   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717208(3-[4-(4-fluorophenyl)-5-{2-[4- (4-methylpiperazin-...)
Affinity DataIC50: 0.111nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717208(3-[4-(4-fluorophenyl)-5-{2-[4- (4-methylpiperazin-...)
Affinity DataIC50: 0.0770nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent