BDBM717194 3-[3-(4-fluorophenyl)-4-{8-[4- (4-methylpiperazin-1-yl)phenyl]- 9H-purin-6-y1}-1H-pyrazol-1- yl]propan-1-ol::US20250034159, Example 15

SMILES CN1CCN(c2ccc(-c3nc4c(-c5cn(CCCO)nc5-c5ccc(F)cc5)ncnc4[nH]3)cc2)CC1

InChI Key InChIKey=ZVPUQIMWMAXCGB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717194   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717194(3-[3-(4-fluorophenyl)-4-{8-[4- (4-methylpiperazin-...)
Affinity DataIC50: 0.270nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717194(3-[3-(4-fluorophenyl)-4-{8-[4- (4-methylpiperazin-...)
Affinity DataIC50: 0.207nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent