BDBM717186 3-[3-(4-fluorophenyl)-4-(8- phenyl-9H-purin-6-yl)-1H- pyrazol-1-yl]propan-1-ol::US20250034159, Example 6

SMILES OCCCn1cc(-c2ncnc3[nH]c(-c4ccccc4)nc23)c(-c2ccc(F)cc2)n1

InChI Key InChIKey=IJDDQOASTFZBLX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717186   

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717186(3-[3-(4-fluorophenyl)-4-(8- phenyl-9H-purin-6-yl)-...)
Affinity DataIC50: 0.253nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717186(3-[3-(4-fluorophenyl)-4-(8- phenyl-9H-purin-6-yl)-...)
Affinity DataIC50: 0.148nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent