BDBM716971 N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{6-ethyl-7-[4-(5-hydroxy-6- methylpyrimidine-4-carbonyl)piperazin-1-yl]-2-[(2- methylcyclobutylidene)methyl]-8-oxo-5H,8H-pyrido[2,3-b]pyrazin-5- yl}acetamide::US20250034136, Compound I-142

SMILES CCc5c(N2CCN(C(=O)c1ncnc(C)c1O)CC2)c(=O)c4nc(/C=C/3CCC3C)cnc4n5CC(=O)Nc6ccc(C(F)(F)F)cc6Cl

InChI Key InChIKey=HPJIAXMGUHIRFY-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 716971   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1235,L1074F](Human)
Nimbus Wadjet

US Patent

LigandBDBM716971(N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{6-ethyl-...)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:Bovine skin gelatin (BSG), dimethyl sulfoxide (DMSO), Pluronic F-127 and tris(2-carboxyethyl)phosphine hydrochloride solution (TCEP) were purchased f...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/5/2025
Entry Details
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