BDBM716208 4-(6-(6-(3-(3-fluoropyridin-2-yl)prop-2-yn-1-yl)piperazin-3-yl)pyridin-3-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazoline[1,5-a]pyridine-3-carbonitrile::US12209085, Example 257

SMILES Cn6cc(c5cc(c3ccc(N2CCN(CC#Cc1ncccc1F)CC2)nc3)c4c(C#N)cnn4c5)cn6

InChI Key InChIKey=PPSNSGMDVNKHHG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 716208   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716208(4-(6-(6-(3-(3-fluoropyridin-2-yl)prop-2-yn-1-yl)pi...)
Affinity DataIC50: 0.170nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716208(4-(6-(6-(3-(3-fluoropyridin-2-yl)prop-2-yn-1-yl)pi...)
Affinity DataIC50: 0.740nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent