BDBM716198 US12209085, Example 247

SMILES Cn1cc(-c2cc(-c3ccc(N4CCN(CC#Cc5ccccn5)CC4)nc3)c3c(C#N)cnn3c2)cn1

InChI Key InChIKey=NDXJPXQNUXPSTO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 716198   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716198(US12209085, Example 247)
Affinity DataIC50: 0.150nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716198(US12209085, Example 247)
Affinity DataIC50: 1.94nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent