BDBM716112 US12209085, Example 1::US20250115576, Example 7

SMILES Cn6cc(c5cc(c3ccc(N2CCN(C(=O)C#Cc1ccccc1)CC2)nc3)c4c(C#N)cnn4c5)cn6

InChI Key InChIKey=YEYOIWDLFZJGMH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 716112   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 0.610nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 0.870nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 0.970nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 0.950nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 5.53nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 4.88nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 1.16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent