BDBM715696 (S)-1-amino-1'-(5-(2,3-dichlorophenyl)-3-(hydroxymethyl)-6-methylpyrazin-2-yl)-1,3-dihydrospiro[indene-2,4'-piperidine]-6-carbonitrile ::US12209074, Example 2

SMILES Cc1nc(N2CCC3(CC2)Cc2ccc(C#N)cc2[C@H]3N)c(CO)nc1-c1cccc(Cl)c1Cl

InChI Key InChIKey=WAIQKUOAWIADDP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 715696   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Beijing Shenogen Pharma Group

US Patent
LigandPNGBDBM715696((S)-1-amino-1'-(5-(2,3-dichlorophenyl)-3-(hydroxym...)
Affinity DataIC50: 35nMAssay Description:The basic principle is: SHP2 as phosphatase can catalyze the dephosphorization of DiFMUP to form DiFMU and free phosphate groups. The product DiFMU e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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