BDBM715312 US20250026748, Compound 476

SMILES COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1

InChI Key InChIKey=ZAEYDSHIXXLWTJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 715312   

TargetCytochrome P450 3A4(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 1.17E+3nMAssay Description:A seven-point semi-log dilution of each test compound (up to 30 NM) or positive control inhibitors for CYP2C9 (up to 1000 nM sulphenazole), CYP2D6 (u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed