BDBM715294 US20250026748, Compound 458

SMILES COc1cnc(C(F)F)cc1-c1cc(-n2ccnc(C)c2=O)ncc1C(=O)Nc1nnc(C#CC2CC2)s1

InChI Key InChIKey=FJSDTBYWFVRGIC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 715294   

TargetDNA polymerase theta(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM715294(US20250026748, Compound 458)
Affinity DataIC50: 0.100nMAssay Description:PolQ ATPase enzyme (1-894) at 0.5 nM is incubated with a 10-point concentration response of inhibitors for 15 min at rt in the following buffer: 50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent