BDBM714963 US20250026748, Compound 127

SMILES COc1cnc(C(F)F)cc1c3cc(c2ccnn2C)ncc3C(=O)Nc5nnc(C#CC4CC4)s5

InChI Key InChIKey=UNVJWTSYKUIUMH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 714963   

TargetDNA polymerase theta(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM714963(US20250026748, Compound 127)
Affinity DataIC50: 0.25nMAssay Description:PolQ ATPase enzyme (1-894) at 0.5 nM is incubated with a 10-point concentration response of inhibitors for 15 min at rt in the following buffer: 50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent