BDBM714694 US20250026741, Compound #40

SMILES O=C1/C(=C/c2ccc(-c3ccc(O)c(C(=O)O)c3)o2)CCC/C1=Cc1ccc(-c2ccc(O)c(C(=O)O)c2)o1

InChI Key InChIKey=GMEZLOIXNCNKAP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 714694   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714694(US20250026741, Compound #40)
Affinity DataIC50: 1.00E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714694(US20250026741, Compound #40)
Affinity DataIC50: 1.00E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [248-527](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714694(US20250026741, Compound #40)
Affinity DataIC50: 1.00E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent