BDBM714658 US20250026741, Compound #04

SMILES N/N=C(N)c1cc(-c2ccc(/C=C3Sc4ccccc4C3=O)o2)ccc1O

InChI Key InChIKey=KMNCHGYPKOFXRN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 714658   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714658(US20250026741, Compound #04)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714658(US20250026741, Compound #04)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [248-527](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714658(US20250026741, Compound #04)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714658(US20250026741, Compound #04)
Affinity DataIC50: 2.00E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714658(US20250026741, Compound #04)
Affinity DataIC50: 5.30E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 5(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714658(US20250026741, Compound #04)
Affinity DataIC50: 7.70E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent