BDBM714655 US20250026741, Compound #01

SMILES Nc1ccc(NC(=O)c2cc(-c3ccc(/C=C4Sc5ccccc5C4=O)o3)ccc2O)cc1

InChI Key InChIKey=QIHPYOMHJKWGKL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 714655   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714655(US20250026741, Compound #01)
Affinity DataIC50: 1.00E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714655(US20250026741, Compound #01)
Affinity DataIC50: 1.05E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [248-527](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714655(US20250026741, Compound #01)
Affinity DataIC50: 1.00E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714655(US20250026741, Compound #01)
Affinity DataIC50: 220nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714655(US20250026741, Compound #01)
Affinity DataIC50: 6.80E+3nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 5 (PTPN5)(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM714655(US20250026741, Compound #01)
Affinity DataIC50: 4.40E+4nMAssay Description:To test the synthesized compounds for their potential to inhibit SHP2 activity, a fluorescence intensity-based assay using 6,8-difluoro-4-methylumbel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent