BDBM713026 US20250019385, Example II-10

SMILES C[C@H](Oc1nc(-c2noc3c2CCC[C@@]32CCCc3sc(N)c(C#N)c32)nc2c1CCCO[C@]21CCOC1)[C@@H]1CCCN1C

InChI Key InChIKey=JLEBPUHEDRECFJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 713026   

TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 1nMAssay Description:This assay can be used to examine the potency with which compounds according to the invention binding to (mutated) KRAS inhibit the protein-protein i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169,G12C,C51S,C80L,C118S]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 1nMAssay Description:This assay can be used to examine the potency with which compounds according to the invention binding to (mutated) KRAS inhibit the protein-protein i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 56nMAssay Description:This assay measures the inhibitory effect of compounds on KRAS CRAF protein protein interactions in the presence of GTP using Time-resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169,G12V,C118S]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 38nMAssay Description:This assay measures the inhibitory effect of compounds on KRAS CRAF protein protein interactions in the presence of GTP using Time-resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 128nMAssay Description:This assay measures the inhibitory effect of compounds on KRAS CRAF protein protein interactions in the presence of GTP using Time-resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 56nMAssay Description:This assay measures the inhibitory effect of compounds on KRAS CRAF protein protein interactions in the presence of GTP using Time-resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169,G12V,C118S]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 38nMAssay Description:This assay measures the inhibitory effect of compounds on KRAS CRAF protein protein interactions in the presence of GTP using Time-resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM713026(US20250019385, Example II-10)
Affinity DataIC50: 128nMAssay Description:This assay measures the inhibitory effect of compounds on KRAS CRAF protein protein interactions in the presence of GTP using Time-resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent