BDBM712985 US20250019385, Example I-31

SMILES CO[C@H]1C[C@@H](n2c(=O)n(C)c3c(O[C@@H](C)[C@@H]4CCCN4C)nc(-c4onc5c4CCC[C@@]54CCCc5sc(N)c(C#N)c54)nc32)C1

InChI Key InChIKey=CERJDVRGYIBZJJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 712985   

TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM712985(US20250019385, Example I-31)
Affinity DataIC50: 1nMAssay Description:This assay can be used to examine the potency with which compounds according to the invention binding to (mutated) KRAS inhibit the protein-protein i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetGTPase KRas [1-169,G12C,C51S,C80L,C118S]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM712985(US20250019385, Example I-31)
Affinity DataIC50: 2nMAssay Description:This assay can be used to examine the potency with which compounds according to the invention binding to (mutated) KRAS inhibit the protein-protein i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent