BDBM712323 6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quinolin-1-yl]-1,2,3,4- tetrahydroisoquinoline::US20250011319, Compound 1.32

SMILES COc1ccc(-c2nn(-c3ccc4c(c3)CCNC4)c3c2cnc2ccccc23)cc1OC

InChI Key InChIKey=UGYNEACLDYDYAB-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 712323   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712323(6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712323(6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712323(6-[3-(3,4-dimethoxyphenyl)-1H- pyrazolo[4,3-c]quin...)
Affinity DataKi: >50nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent