BDBM712320 5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[4,3-c]quinolin-1-yl]-2,3-dihydro- 1H-isoindole::US20250011319, Compound 1.36

SMILES COC1=CC2c3c(c(C4=CC(OC)C(OC)C=C4)nn3C3C=C4CNCC4=CC3)C=NC2C=C1

InChI Key InChIKey=GGKRTZSGWIAUPT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 712320   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi: <10nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712320(5-[3-(3,4-dimethoxyphenyl)-8-methoxy-1H- pyrazolo[...)
Affinity DataKi:  15nMAssay Description:Table D: Corresponding biochemical inhibition of enzymatic activities of FLT3 (wt), FLT3 (D835Y), and FLT3 (ITD) were measured using recombinant prot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent