BDBM712309 1-{3-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazolo[4,3-c]quinolin-3-yl]phenyl}- 4-methylpiperazine::US20250011319, Compound 1.3

SMILES COC1=CC2C(C=C1)N=CC1C(C3C=C(N4CCN(C)CC4)C=CC3)=NN(C3=CC(C)C(C)C=C3)C12

InChI Key InChIKey=WFUGRLMOKPDCMW-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 712309   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lomond Therapeutics

US Patent
LigandPNGBDBM712309(1-{3-[1-(3,4-dimethylphenyl)-8-methoxy- 1H-pyrazol...)
Affinity DataKi:  15nMAssay Description:Table A: Primary Assay used to determine potency of HPK1 enzymatic activity inhibition. Compound activity was determined using recombinant HPK1 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent