BDBM712247 (3,4- Dihydroisoquinolin-2(1H)- yl)(5-(2,4,5-trifluoro-3- hydroxyphenyl)-1,2,4- oxadiazol-3-yl) methanone::US20250011311, Example 64

SMILES O=C(c1noc(-c2cc(F)c(F)c(O)c2F)n1)N1CCc2ccccc2C1

InChI Key InChIKey=LRTRBWMJBKVQIH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 712247   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Astrazeneca

US Patent
LigandPNGBDBM712247((3,4- Dihydroisoquinolin-2(1H)- yl)(5-(2,4,5-trifl...)
Affinity DataIC50: 48nMAssay Description:Final assay conditions were 80 nM of 17bHSD13, 0.5 mM of NAD, 20 μM Estradiol and various concentrations of compound in buffer (5 mM EDTA (TEKNOVA E0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Astrazeneca

US Patent
LigandPNGBDBM712247((3,4- Dihydroisoquinolin-2(1H)- yl)(5-(2,4,5-trifl...)
Affinity DataIC50: 5.60E+3nMAssay Description:10 concentration of compounds (0.2 μl) in DMSO was added to GREINER FLUOTRAC 200 384 well plate (781076) using ECHO dispensing (BECKMAN COULTER). 80 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
Go to US Patent