BDBM71202 US11724992, Compound 186a::US11724992, Example 93

SMILES CC(C)n1ccc([S@@](N)(=O)=NC(=O)Nc2c3c(cc4c2CCC4)CCC3)n1

InChI Key InChIKey=MMPSDZURSJKDME-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 71202   

LigandChemical structure of BindingDB Monomer ID 71202BDBM71202(US11724992, Example 93 | US11724992, Compound 186a)
Affinity DataIC50: 120nMAssay Description:THP-1 cells were purchased from the American Type Culture Collection and sub-cultured according to instructions from the supplier. Prior to experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 71202BDBM71202(US11724992, Example 93 | US11724992, Compound 186a)
Affinity DataIC50: 5.50E+3nMAssay Description:Antagonist activity against NLRP3 in PMA-primed human THP-1 cells assessed as inhibition of gramicidin-induced IL-1beta release measured after 1 hr i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed