BDBM711128 2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-triazol-3-yl)cyclobutyl)phenyl)-6-(((1- (methoxymethyl)cyclopropyl)amino)methyl)- 4-(trifluoromethyl)isoindolin-1-one::US12187709, Compound 487

SMILES COCC1(NCc2cc3c(c(C(F)(F)F)c2)CN(c2cccc([C@]4(c5nncn5C)C[C@H](OC)C4)c2)C3=O)CC1

InChI Key InChIKey=WQGHFGVHDRESMV-UHFFFAOYSA-N

Data  3 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 711128   

LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataIC50: 19nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataIC50: 150nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  4.90nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  210nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM711128(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  210nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed