BDBM710715 2-(3-(6-(4-methyl-4H-1,2,4-triazol-3-yl)-2- oxaspiro[3.3]heptan-6-yl)phenyl)-6-(((1- methylcyclobutyl)amino)methyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 65

SMILES Cn1cnnc1C7(c5cccc(N4Cc3c(cc(CNC2(C)CCC2)cc3C(F)(F)F)C4=O)c5)CC6(COC6)C7

InChI Key InChIKey=HCJLZDRUCWBKBD-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710715   

LigandPNGBDBM710715(2-(3-(6-(4-methyl-4H-1,2,4-triazol-3-yl)-2- oxaspi...)
Affinity DataIC50: 20nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
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LigandPNGBDBM710715(2-(3-(6-(4-methyl-4H-1,2,4-triazol-3-yl)-2- oxaspi...)
Affinity DataIC50: 62nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710715(2-(3-(6-(4-methyl-4H-1,2,4-triazol-3-yl)-2- oxaspi...)
Affinity DataKd:  3.70nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710715(2-(3-(6-(4-methyl-4H-1,2,4-triazol-3-yl)-2- oxaspi...)
Affinity DataKd:  68nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent