BDBM710714 (1R,3s)-3-(3-(6-(((S)-2-isopropyl-4- methylpiperazin-1-yl)methyl)-1-oxo-4- (trifluoromethyl)isoindolin-2-yl)phenyl)-3- (4-methyl-4H-1,2,4-triazol-3- yl)cyclobutanecarbonitrile::US12187709, Compound 64

SMILES CC(C)[C@H]1CN(C)CCN1Cc1cc2c(c(C(F)(F)F)c1)CN(c1cccc([C@]3(c4nncn4C)C[C@@H](C#N)C3)c1)C2=O

InChI Key InChIKey=AIKXFQYBAQZYOI-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710714   

LigandPNGBDBM710714((1R,3s)-3-(3-(6-(((S)-2-isopropyl-4- methylpiperaz...)
Affinity DataIC50: 24nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

LigandPNGBDBM710714((1R,3s)-3-(3-(6-(((S)-2-isopropyl-4- methylpiperaz...)
Affinity DataIC50: 70nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710714((1R,3s)-3-(3-(6-(((S)-2-isopropyl-4- methylpiperaz...)
Affinity DataKd:  16nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710714((1R,3s)-3-(3-(6-(((S)-2-isopropyl-4- methylpiperaz...)
Affinity DataKd:  81nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent