BDBM710687 (S)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluoro-1-(4-methyl-4H-1,2,4-triazol-3- yl)cyclobutyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 37

SMILES C[C@H](NC1CCC1)c1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3(c4nncn4C)CC(F)(F)C3)c1)C2=O

InChI Key InChIKey=YISJYTBPXCDWRG-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710687   

LigandPNGBDBM710687((S)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluo...)
Affinity DataIC50: 6.60nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

LigandPNGBDBM710687((S)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluo...)
Affinity DataIC50: 9.90nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710687((S)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluo...)
Affinity DataKd:  0.800nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710687((S)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluo...)
Affinity DataKd:  3.80nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent