BDBM710674 (1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3-yl)-3- (3-(6-(((1-methylcyclobutyl)amino)methyl)- 1-oxo-4-(trifluoromethyl)isoindolin-2- yl)phenyl)cyclobutanecarbonitrile::US12187709, Compound 24

SMILES Cn1cnnc1[C@]1(c2cccc(N3Cc4c(cc(CNC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)C[C@@H](C#N)C1

InChI Key InChIKey=OZWSLBMKAZOPGU-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710674   

LigandPNGBDBM710674((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3-yl)-3- (3-(...)
Affinity DataIC50: 13nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
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LigandPNGBDBM710674((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3-yl)-3- (3-(...)
Affinity DataIC50: 23nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710674((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3-yl)-3- (3-(...)
Affinity DataKd:  1.70nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710674((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3-yl)-3- (3-(...)
Affinity DataKd:  15nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent