BDBM710665 6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl)-2-(3-((S)-((1r,3S)-3- methoxyclobutyl)(4-methyl-4H-1,2,4- triaozl-3-yl)methyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 15

SMILES COC6CC([C@@H](c4cccc(N3Cc2c(cc(CN1CCN(C)C[C@@H]1C(C)C)cc2C(F)F)C3=O)c4)c5nncn5C)C6

InChI Key InChIKey=YJMWLWKXYJRSBL-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710665   

LigandPNGBDBM710665(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataIC50: 1.90E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

LigandPNGBDBM710665(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataIC50: 4.90E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710665(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataKd:  770nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710665(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataKd:  1.10E+4nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
Go to US Patent