BDBM709717 (5'S,7a'R)-1-[2- (difluoromethyl)pyrimidin- 4-yl]-5'-(3,5- difluorophenyl)tetrahydro- 3'H-spiro[piperidine-4,2'- pyrrolo[2,1-b] [1,3]oxazol]-3'-one::US12180226, Example 4.9

SMILES O=C1N2[C@@H](CC[C@H]2c2cc(F)cc(F)c2)OC12CCN(c1ccnc(C(F)F)n1)CC2

InChI Key InChIKey=NPVRUWDREYDXNH-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 709717   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM709717((5'S,7a'R)-1-[2- (difluoromethyl)pyrimidin- 4-yl]-...)
Affinity DataEC50: <2.50E+4nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
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