BDBM709658 N-((1S,3S)-3-(4-(4- (3-cyano-4- methoxypyrazolo[1, 5-a]pyridin-6-yl)- 1H-pyrazol-1- yl)piperidine-1- carbonyl)cyclopentyl)- ethenesulfonamide::US12180207, Example 190

SMILES C=CS(=O)(=O)N[C@H]1CC[C@H](C(=O)N2CCC(n3cc(-c4cc(OC)c5c(C#N)cnn5c4)cn3)CC2)C1

InChI Key InChIKey=JWBKKCJZIDXHLG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 709658   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709658(N-((1S,3S)-3-(4-(4- (3-cyano-4- methoxypyrazolo[1,...)
Affinity DataIC50: 37nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709658(N-((1S,3S)-3-(4-(4- (3-cyano-4- methoxypyrazolo[1,...)
Affinity DataIC50: 3nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709658(N-((1S,3S)-3-(4-(4- (3-cyano-4- methoxypyrazolo[1,...)
Affinity DataIC50: 9nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709658(N-((1S,3S)-3-(4-(4- (3-cyano-4- methoxypyrazolo[1,...)
Affinity DataIC50: 3nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709658(N-((1S,3S)-3-(4-(4- (3-cyano-4- methoxypyrazolo[1,...)
Affinity DataIC50: 1nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent