BDBM709627 (E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3- methoxyazetidine-3- carbonyl)piperidin- 4-yl)-5-methyl-1H- pyrazol-4-yl)-4- methoxypyrazolo [1,5-a]pyridine-3- carbonitrile::US12180207, Example 158

SMILES COc1cc(-c2cnn(C3CCN(C(=O)C4(OC)CN(C(=O)/C=C/CN(C)C)C4)CC3)c2C)cn2ncc(C#N)c12

InChI Key InChIKey=LVRQYRWZIOHHHF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 709627   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709627((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 168nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709627((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 8nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709627((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 2nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709627((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 77nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709627((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 30nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709627((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 8nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent